The 2015 film Detective Conan: Gōka no Himawari (Detective Conan: Sunflowers of Inferno) held the previous record, with 4.48 billion yen (about US$41.6 million) in box-office earnings.
The anime film franchise now exceeds 60 billion yen (about US$557.6 million) in total box-office earnings.
Detective Conan: The Darkest Nightmare sold 933,800 tickets for 1.209 billion yen (about US$11.1 million) to top the Japanese box office in its opening weekend, and earning the highest opening weekend gross in the franchise's history.
The film features members of the story's Black Organization who have previously appeared in the series: Gin, Vodka, Vermouth, Chianti, Korn, Kir, and Bourbon. The film's website also hints at the appearance of Rum, who has never been shown in the series.
Yūki Amami guest stars in the film as the "mysterious woman" whose eyes are different colors and who is a member of the Black Organization. Rock band B'z is performing the film's theme song "Sekai wa Anata no Iro ni Naru."